2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Cytochrome P450

Cytochrome P450

CYPs

Cytochrome P450

Related Products

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Cytochrome p450 comprises a superfamily of heme-thiolate proteins named for the spectral absorbance peak of their carbon-monoxide-bound species at 450 nm. Having been found in every class of organism, including Archaea, the p450 superfamily is believed to have originated from an ancestral gene that existed over 3 billion years ago. Repeated gene duplications have subsequently given rise to one of the largest of multigene families. These enzymes are notable both for the diversity of reactions that they catalyze and the range of chemically dissimilar substrates upon which they act. Cytochrome p450s support the oxidative, peroxidative and reductive metabolism of such endogenous and xenobiotic substrates as environmental pollutants, agrochemicals, plant allelochemicals, steroids, prostaglandins and fatty acids. In humans, Cytochrome p450s are best known for their central role in phase I drug metabolism where they are of critical importance to two of the most significant problems in clinical pharmacology: drug interactions and interindividual variability in drug metabolism.

Cytochrome P450 Isoform Specific Products:

Cytochrome P450 Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N2262R
    8-Geranyloxypsoralen (Standard)
    		Inhibitor
    8-Geranyloxypsoralen (Standard) is the analytical standard of 8-Geranyloxypsoralen. This product is intended for research and analytical applications. 8-Geranyloxypsoralen is a furanocoumarin isolated from grapefruit, acts as a potent inhibitor of P450 3A4 (CYP3A4) with an IC50 of 3.93 μM.
    8-Geranyloxypsoralen (Standard)
  • HY-B0407AR
    Chlorpromazine (hydrochloride) (Standard)
    		Inhibitor
    Chlorpromazine (hydrochloride) (Standard) is the analytical standard of Chlorpromazine (hydrochloride). This product is intended for research and analytical applications. Chlorpromazine hydrochloride is an orally active, blood-brain barrier-transparent antipsychotic agent that effectively antagonises D2 dopamine receptors and 5-HT2A, which is widely used in schizophrenia and other psychiatric disorders. Chlorpromazine hydrochloride exerts anti-cancer activity through a variety of pathways, including anti-proliferation, induction of autophagy and cycle arrest (G2-M phase), inhibition of cytochrome c oxidase (CcO), inhibition of tumour growth and metastasis, and inhibition of tumour immune escape. Chlorpromazine hydrochloride also blocks hNav1.7 channels (IC50=25.9 μM; concentration-dependent) and HERG potassium channels (IC50=21.6 μM), which has potential for analgesic and cardiac arrhythmic studies. Chlorpromazine hydrochloride also can inhibit clathrin-mediated endocytosis.
    Chlorpromazine (hydrochloride) (Standard)
  • HY-13632S5
    Exemestane-13C,d2
    		Inhibitor
    Exemestane-13C,d2 is 13C and deuterated labeled Exemestane (HY-13632). Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC50s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research.
    Exemestane-<sup>13</sup>C,d<sub>2</sub>
  • HY-B0725S
    Doxepin-d3 hydrochloride
    		Inhibitor 98.68%
    Doxepin-d3 (hydrochloride) is a deuterium labeled Doxepin Hydrochloride. Doxepin hydrochloride is an orally active tricyclic antidepressant. Doxepin hydrochloride is a potent and selective histamine receptor H1 antagonist. Doxepin hydrochloride is also a potent CYP450 inhibitor and significantly inhibits CYP450 2C19 and 1A2[1][2].
    Doxepin-d<sub>3</sub> hydrochloride
  • HY-147807
    HIV-1 inhibitor-40
    		Inhibitor
    HIV-1 inhibitor-40 (Compound 4ab) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) of HIV-1 with an EC50 of 1.9 nM. HIV-1 inhibitor-40 displays weak CYP sensitivity with IC50 values of 5.16 μM and 4.51 μM against CYP2C9 and CYP2C19, respectively. HIV-1 inhibitor-40 has no apparent in vivo acute toxicity.
    HIV-1 inhibitor-40
  • HY-B0885R
    Econazole (Standard)
    		Inhibitor
    Econazole (Standard) ((±)-Econazol (Standard)) is the analytical standard of Econazole (HY-B0885). This product is intended for research and analytical applications. Econazole ((±)-Econazol) is an orally active imidazole antifungal agent, as well as a cytochrome P-450 inhibitor and a blocker of calcium and manganese ion uptake. Econazole is active against a variety of fungi and some Gram-positive bacteria, but has no significant activity against Gram-negative bacteria. Econazole can inhibit the synthesis of prostaglandins and can also induce liver damage.
    Econazole (Standard)
  • HY-170929
    EMT inhibitor-3
    		Activator
    EMT inhibitor-3 (compound 11i) is a epithelial-mesenchymal transition (EMT) inhibitor. EMT inhibitor-3 inhibits neuroblastoma SK-N-SH cells with an IC50 of 2.5 μM. EMT inhibitor-3 inhibits SK-N-SH cell proliferation, migration, and invasion. EMT inhibitor-3 increases the Bax/Bcl-2 protein expression ratio, promotes Cytochrome C ( HY-125857) release from mitochondria, and activates caspases 9 and caspases 3, inducing mitochondria-mediated endogenous tumor cell Apoptosis. EMT inhibitor-3 is potential for cancer research.
    EMT inhibitor-3
  • HY-121213
    Erysolin
    		Inhibitor
    Erysolin is a CYP1A inhibitor with antigenic toxicity. Erysolin reduces benzo(a)pyrene-induced genotoxicity.
    Erysolin
  • HY-B0940S
    Ethylvanillin-d5
    Ethylvanillin-d5 is a deuterium labeled Ethylvanillin (HY-B0940).
    Ethylvanillin-d<sub>5</sub>
  • HY-E70507
    Human CYP2A6,High-Reductase+b5
    Human CYP2A6, High-Reductase+b5, a recombinant CYP2A6, is a member of the CYP enzyme family and is responsible for the metabolic activation of most tobacco carcinogens.
    Human CYP2A6,High-Reductase+b5
  • HY-N5011R
    5,7-Dimethoxyflavone (Standard)
    		Inhibitor
    5,7-Dimethoxyflavone (Standard) is the analytical standard of 5,7-Dimethoxyflavone. This product is intended for research and analytical applications. 5,7-Dimethoxyflavone is one of the major components of Kaempferia parviflora, has anti-obesity, anti-inflammatory, and antineoplastic effects. 5,7-Dimethoxyflavone inhibits cytochrome P450 (CYP) 3As. 5,7-Dimethoxyflavone is also a potent Breast Cancer Resistance Protein (BCRP) inhibitor.
    5,7-Dimethoxyflavone (Standard)
  • HY-E70511
    Human CYP46A1,High-Reductase
    Human CYP46A1, High-Reductase, a recombinant CYP46A1, is a member of the CYP enzyme family. CYP46A1 is expressed mainly in brain neurons and is responsible for brain cholesterol homeostasis by regulating the cholesterol efflux.
    Human CYP46A1,High-Reductase
  • HY-E70492
    Human CYP2C8,Low-Reductase
    Human CYP2C8, Low-Reductase, a recombinant CYP2C8, is a member of the CYP enzyme family and is involved in the metabolism of xenobiotics in the body.
    Human CYP2C8,Low-Reductase
  • HY-E70497
    Human CYP3A7,Low-Reductase+b5
    Human CYP3A7, Low-Reductase+b5, a recombinant CYP3A7, a major fetal‐type P450 enzyme is mainly expressed in the human fetal liver and intestine.
    Human CYP3A7,Low-Reductase+b5
  • HY-B1751A
    Quinidine sulfate
    		Inhibitor
    Quinidine Monosulfate is an antiarrhythmic agent. Quinidine Monosulfate is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine Monosulfate is also a K+ channel blocker with an IC50 of 19.9 μM, and can induce apoptosis. Quinidine Monosulfate can be used for malaria research.
    Quinidine sulfate
  • HY-E70513
    Human CYP26A1,Low-Reductase
    Human CYP26A1, Low-Reductase, a recombinant CYP26A1, is a member of the CYP enzyme family and is the predominant Retinoic acid hydroxylase.
    Human CYP26A1,Low-Reductase
  • HY-161700
    BMS-737
    BMS-737 (compound 33) is a non-steroidal, reversible small molecule inhibitor. BMS-737 exhibits 11-fold selectivity for CYP17 lyase over CYP17 hydroxylase. BMS-737 is designed to inhibit castration-resistant prostate cancer (CRPC) and significantly reduces testosterone levels without significant effects on orrodermal hormone and glucocorticoid levels.
    BMS-737
  • HY-N2372R
    Fraxinol (Standard)
    		Inhibitor
    Fraxinol (Standard) is the analytical standard of Fraxinol. This product is intended for research and analytical applications. Fraxinol is isolated from Lobelia chinensis.
    Fraxinol (Standard)
  • HY-17367S4
    Atazanavir-d6
    		Inhibitor 99.28%
    Atazanavir-d6 is deuterium labeled Atazanavir. Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration[1]. Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp)[2]. Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM[3].
    Atazanavir-d<sub>6</sub>
  • HY-159143
    BChE-IN-33
    		Inhibitor
    BChE-IN-33 (compound 4r), an arylaminonaphthol derivative, is a potent butyrylcholinesterase (BChE) inhibitor with an IC50 of 14.78 µM. BChE-IN-33 also inhibits CYP2C19, CYP2C9, CYP2D6. BChE-IN-33 shows potent antioxidant activity with IC50 values of 150.48 μM, 2.56 μM and 4.61 μM by DPPH, ABTS, Ferric-phenanthroline assay, respectively. BChE-IN-33 has the potential for Alzheimer research.
    BChE-IN-33
Cat. No. Product Name / Synonyms Application Reactivity
Cytochrome P450 Isoform Comparison

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